Observational Studies Analyzed Like Randomized Experiments
نویسندگان
چکیده
منابع مشابه
REJOINDER Authors’ Response, Part I: Observational Studies Analyzed Like Randomized Experiments Best of Both Worlds
W e thank the 3 discussants for their contributions. The Women’ Health Initiative (WHI) investigators found a greater CHD risk in the estrogen plus progestin (ie, combined hormone) therapy arm than in the placebo arm of the trial (hazard ratio HR : 1.24, 95% confidence interval CI : 1.00–1.54). In contrast, the Nurses’ Health Study (NHS) investigators found a lower CHD risk in current users of ...
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BACKGROUND The Women's Health Initiative randomized trial found greater coronary heart disease (CHD) risk in women assigned to estrogen/progestin therapy than in those assigned to placebo. Observational studies had previously suggested reduced CHD risk in hormone users. METHODS Using data from the observational Nurses' Health Study, we emulated the design and intention-to-treat (ITT) analysis...
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ژورنال
عنوان ژورنال: Epidemiology
سال: 2008
ISSN: 1044-3983
DOI: 10.1097/ede.0b013e3181875e61